data = [['ABC', 12, 3, 100], ['DEF', 10, 5, 200], ['GHI', 13, 3, 1000]] data.sort(key=lambda row: (row[2], row[3]), reverse=True) print(data) # [['DEF', 10, 5, 200], ['GHI', 13, 3, 1000], ['ABC', 12, 3, 100]]